Sadie makes a return to the starting line-up at tighthead prop, while Nothnagel (lock) and Sangweni (flanker) will be collecting their first starting berths in the Vodacom URC.
Nothnagel comes in for the injured Pieter Jansen van Vuren, while Sangweni features in what reflects a few selection rotations in the match 23.
Commenting on last week's performance against Glasgow Warriors, Emirates Lions head coach Ivan van Rooyen was upbeat ahead of his team's fourth round encounter.
"There were quite a few aspects we felt we improved on in our performance against Glasgow Warriors last week, and that's the kind of momentum we want to take into the Ulster game," said Van Rooyen.
"This is the final game of our four-week tour, so naturally we want to end it on a high."
Wilhelm van der Sluys (lock), Emmanuel Tshituka (loose forward) and Fred Zeilinga (flyhalf) will all have an opportunity to make their tournament debuts off the bench on Friday.
The match kicks off at 20h35 (SA time) and will be broadcast live on SuperSport.
Emirates Lions: 15 Divan Rossouw, 14 Stean Pienaar, 13 Manuel Rass, 12 Burger Odendaal (captain), 11 Rabz Maxwane, 10 EW Viljoen, 9 Andre Warner, 8 Ruhan Straeuli, 7 Vincent Tshituka, 6 Sibusiso Sangweni, 5 Reinard Nothnagel, 4 Ruben Schoeman, 3 Carlu Sadie, 2 Jaco Visagie, 1 Sti Sithole. Replacements: 16 PJ Botha, 17 Ruan Dreyer, 18 Asenathi Ntlabakanye, 19 Wilhelm van der Sluys, 20 Emmanuel Tshituka, 21 Morne van den Berg, 22 Fred Zeilinga, 23 Wandisile Simelane.