Two of the changes are in the tight five and there is one injury-enforced change in the DHL Stormers backline for the first-ever match between these two teams, which kicks off at 19h00 on Friday at Mbombela Stadium.
Edwill van der Merwe (wing) starts out wide in place of the injured Sergeal Petersen, while up front Chris van Zyl (lock) gets a start in a rotational switch and Leon Lyons (loosehead prop) will earn his first DHL Stormers cap.
Lyons was named as a replacement last week but never got on the pitch against the Emirates Lions, with the experienced Steven Kitshoff playing the entire match at DHL Newlands.
Kitshoff and Scarra Ntubeni (hooker) have been isolated according to COVID-19 protocols after coming into contact with someone who has tested positive for the virus.
This means that Kwenzo Blose (prop) and Chad Solomon (hooker) are both among an extended list of replacements along with Jaco Coetzee (flank), Godlen Masimla (scrumhalf) and Tristan Leyds (utility back), none of whom featured last week. The replacements bench will be finalised on Friday.
DHL Stormers head coach John Dobson said that the trip to Nelspruit will be a good chance for his team to show what they learned from their opening match.
“We would like to see growth and improvement in certain areas of our game and an away game in Nelspruit will be a good test of that," said Dobson.
“We have some exciting players coming into the mix this week, so we are looking forward to seeing what they have to offer as we keep building."
DHL Stormers: 15 Warrick Gelant, 14 Edwill van der Merwe, 13 Dan du Plessis, 12 Rikus Pretorius, 11 Leolin Zas, 10 Damian Willemse, 9 Herschel Jantjies, 8 Juarno Augustus, 7 Ernst van Rhyn, 6 Siya Kolisi (captain), 5 Chris van Zyl, 4 Salmaan Moerat, 3 Frans Malherbe, 2 Bongi Mbonambi, 1 Leon Lyons. Replacements (from): 16 Chad Solomon, 17 Kwenzo Blose, 18 Neethling Fouche, 19 JD Schickerling, 20 Nama Xaba, 21 Jaco Coetzee, 22 Godlen Masimla, 23 Michal Haznar, 24 Tim Swiel, 25 Tristan Leyds.