Libbok, a former Junior Springbok who has gained a lot of experience with the Vodacom Bulls and Cell C Sharks, will link up with scrumhalf Paul de Wet, while Stefan Ungerer is also set to make his DHL Stormers debut from the replacements bench.
Rikus Pretorius and Ruhan Nel are in midfield, with Warrick Gelant, Sergeal Petersen and Edwill van der Merwe forming a dangerous back three.
In the forward pack Springbok hooker Scarra Ntubeni will have Leon Lyons and Neethling Fouche either side of him, with Ernst van Rhyn and Salmaan Moerat in the second row.
Deon Fourie and Willie Engelbrecht are on the flanks, with Evan Roos starting at No 8 and Nama Xaba set to make an impact from the bench.
Ntubeni, Moerat, Roos and Gelant are all making their return from injuries which saw them miss the final stages of the Carling Currie Cup.
DHL Stormers Head Coach John Dobson said that his team are determined to get their campaign off to a positive start.
“We have named a strong team for what we know will be a big challenge to start this exciting new era," said Dobson.
“It has been a great week together here in Treviso and we are looking forward to seeing what these combinations can do."
DHL Stormers: 15 Warrick Gelant, 14 Sergeal Petersen, 13 Ruhan Nel, 12 Rikus Pretorius, 11 Edwill van der Merwe, 10 Manie Libbok, 9 Paul de Wet, 8 Evan Roos, 7 Willie Engelbrecht, 6 Deon Fourie, 5 Salmaan Moerat, 4 Ernst van Rhyn, 3 Neethling Fouche, 2 Scarra Ntubeni, 1 Leon Lyons. Replacements: 16 Andre-Hugo Venter, 17 Dian Bleuler, 18 Sazi Sandi, 19 Adre Smith, 20 Nama Xaba, 21 Stefan Ungerer, 22 Tim Swiel, 23 Juan de Jongh.