Orie was with the Bok squad for the first four matches of the season, while Senatla makes his return from injury in the clash against the Johannesburg side which kicks off at 17h00 (SA time) on Saturday. SuperSport will broadcast the clash live.
Another Springbok tourist, Salmaan Moerat, will lead the DHL Stormers and packs down next to Orie at lock, with the rest of the forward pack unchanged from the combination that started the 24-10 victory against the Dragons in Newport last month.
Senatla and Sergeal Petersen start on the wings, with Warrick Gelant at fullback and and Dan du Plessis and Ruhan Nel linking up in midfield.
DHL Stormers head coach John Dobson said that his players are determined to be at their best in their first home game of the campaign, which will have a limited crowd of 2000 spectators in the stands according to government COVID-19 protocols.
“It has been quite some time since we played in front of our faithful fans, so this will be a special occasion for the team and we want to put up a worthy performance," said Dobson.
“It is great to have some of our best players back in the mix and preparations have gone really well, so hopefully that translates onto the pitch on Saturday.
“We were pleased with the progress we made as a team on our tour and we want to build on that and deliver a rousing performance at home,” he said.
DHL Stormers: 15 Warrick Gelant, 14 Sergeal Petersen, 13 Ruhan Nel, 12 Dan du Plessis, 11 Seabelo Senatla, 10 Manie Libbok, 9 Stefan Ungerer, 8 Evan Roos, 7 Willie Engelbrecht, 6 Junior Pokomela, 5 Marvin Orie, 4 Salmaan Moerat (captain), 3 Neethling Fouche, 2 Scarra Ntubeni, 1 Brok Harris. Replacements: 16 Andre-Hugo Venter, 17 Kwenzo Blose, 18 Lee-Marvin Mazibuko, 19 Ernst van Rhyn, 20 Nama Xaba, 21 Godlen Masimla, 22 Rikus Pretorius, 23 Tim Swiel.