The 19-year-old speedster, who was vice-captain of the Vodacom Bulls Under-20 side last year, will be earn a starting berth on the wing at Emirates Airline Park and will be the only uncapped player in the starting XV.
Moodie will be surrounded by a wealth of experience in the Vodacom Bulls backline which will see veteran Springbok flyhalf, Morné Steyn, returning to the starting team alongside scrumhalf Embrose Papier, while the midfield pairing will consist of Harold Vorster and Lionel Mapoe. Kurt-Lee Arendse will start at fullback this weekend with Madosh Tambwe at left wing.
Marcell Coetzee will also be back to lead the side after coming off the bench in last weekend’s match against DHL Stormers.
The front row will see a change with the props as Simphiwe Matanzima dons the No 1 jersey and Jacques van Rooyen starts at tighthead, with Johan Grobbelaar retaining the No 2 jumper.
"The Emirates Lions showed a good fight in their match against the Cell C Sharks last weekend,” said Vodacom Bulls Director of Rugby, Jake White.
"We have no doubt that they will want to build from that and go one better in search of a win in their own back yard this weekend.
"It is always a tough, physical battle against the Emirates Lions. They are a well-coached side that will throw everything at us. We are looking forward to another exciting Vodacom URC encounter."
The match between the Emirates Lions and Vodacom Bulls will kick-off at 15h00, and it will be televised on SuperSport.
Vodacom Bulls: 15 Kurt-Lee Arendse, 14 Canan Moodie, 13 Lionel Mapoe, 12 Harold Vorster, 11 Madosh Tambwe, 10 Morné Steyn, 9 Embrose Papier, 8 Elrigh Louw, 7 Arno Botha, 6 Marcell Coetzee (captain), 5 Ruan Nortje, 4 Walt Steenkamp, 3 Jacques van Rooyen, 2 Johan Grobbelaar, 1 Simphiwe Matanzima. Replacements: 16 Bismarck du Plessis, 17 Lizo Gqoboka, 18 Robert Hunt, 19 Janko Swanepoel, 20 Muller Uys, 21 Zak Burger, 22 Chris Smith, 23 David Kriel.