Smith comes in for regular starter Sti Sithole who has been rested after a series of matches in the competition.
Hooker PJ Botha and centre Manuel Rass come in for Jaco Visagie and Burger Odendaal respectively.
"Jaco and Burger were close contacts earlier in the week, so COVID-19 protocols mean they needed to be away from the team to mitigate risk," said Van Rooyen. "They will be assessed on Monday next week."
Commenting on Smith’s inclusion, the Lions mentor said the loosehead prop was rewarded for great performances across all competitions.
"JP impressed us in both the Carling Currie Cup as well as stints in the Vodacom URC, so we are eager to see what he can offer us from minute one."
The Johannesburg-based side, led by lock Reinhard Nothnagel, will look to continue their positive string of results against northern hemisphere opposition, following wins against Cardiff, Munster and Ospreys in recent weeks.
Van Rooyen however cautioned against taking the foot off the pedal especially against a side who recorded a big win last weekend in Durban.
"Edinburgh were successful last week, so they might fancy their chances up here," said Van Rooyen. "Likewise, we've had a string of positive results in recent weeks which has certainly motivated us to improve on our performances as the tournament progresses."
With the recent announcement by government to relax the COVID-19 restrictions, Van Rooyen believes an increase in fan attendance is a major boost for the sport.
"It's always fantastic playing in front of a packed stadium, so we’re looking forward to experiencing that kind of atmosphere once more with the increased of the number of fans at sports venues. As a team, it certainly plays a huge role from a motivation point of view."
The match kicks off at 16:05 and will be broadcast live on SuperSport.
Emirates Lions: 15. Quan Horn, 14. Rabz Maxwane, 13. Wandisile Simelane, 12. Manuel Rass, 11. Edwill van der Merwe, 10. Jordan Hendrikse, 9. Morne van den Berg, 8. Emmanuel Tshituka, 7. Vincent Tshituka, 6. Francke Horn, 5.Reinhard Nothnagel (captain), 4. Ruben Schoeman, 3. Carlu Sadie, 2. PJ Botha, 1. JP Smith. Replacements: 16. Morne Brandon, 17. Ruan Dreyer, 18. Asenathi Ntlabakanye, 19. Ruan Venter, 20. Sibusiso Sangweni, 21. Andre Warner, 22. Henco van Wyk, 23. Tiaan Swanepoel.