Cheika has named Matías Moroni to start at outside centre in place of Matías Orlando, while the experienced Juan Imhoff will run out at left wing, in place of Lucio Cinti.
Imhoff will have good recollections of playing in Durban. He scored a hat-trick of tries against the Springboks at Hollywoodbets Kings Park in 2015, when the Pumas beat the Boks for the first time, with the flyer becoming the first player to cross the Bok try-line three times in a Test.
Cheika also made some tweaks to the bench, where the uncapped Pedro Rubiolo has been included along with Bautista Delguy and Mayco Vivas.
Argentina team to face the Boks in Durban: 15. Juan Cruz Mallía, 14. Emiliano Boffelli, 13. Matías Moroni, 12. Jerónimo de la Fuente, 11. Juan Imhoff, 10. Santiago Carreras, 9. Gonzalo Bertranou, 8. Pablo Matera, 7. Marcos Kremer, 6. Juan Martín González, 5. Tomás Lavanini, 4. Matías Alemanno, 3. Eduardo Bello, 2. Julián Montoya (captain), 1. Nahuel Tetaz Chaparro. Replacements: 16. Agustín Creevy, 17. Mayco Vivas, 18. Joel Sclavi, 19. Guido Petti, 20. Pedro Rubiolo, 21. Tomás Cubelli, 22. Benjamín Urdapilleta, 23. Bautista Delguy.