Upfront, Tomas Lavanini comes in for Franco Molino, with Pedro Rubiolo shifting to lock, while Juan Martin Gonzalez takes over at flanker from Pablo Matera, who has been named amongst the replacements.
Santiago Grondona also gets a start this week as he replaces the injured Marcos Kremer on the other side of the back row.
In the backline, Gonzalo Garcia has been preferred at scrumhalf, while Matias Moroni has been named at outside centre after playing off the bench in Santiago del Estero.
The other changes are at wing, where Rodrigo Isgro replaces Bautista Delguy, and fullback, with Santiago Carreras taking from Juan Cruz Mallia.
Argentina: 15 Santiago Carreras, 14 Rodrigo Isgro, 13 Matias Moroni, 12 Santiago Chocobares, 11 Mateo Carreras, 10 Tomas Albornoz, 9 Gonzalo Garcia, 8 Joaquin Oviedo, 7 Santiago Grondona, 6 Juan Martin Gonzalez, 5 Tomas Lavanini, 4 Pedro Rubiolo, 3 Joel Sclavi, 2 Julian Montoya (captain), 1 Thomas Gallo. Replacements: 16 Ignacio Ruiz, 17 Ignacio Calles, 18 Pedro Delgado, 19 Franco Molina, 20 Pablo Matera, 21 Lautaro Bazan Velez, 22 Lucio Cinti, 23 Juan Cruz Mallia.