The game, which kicks off at 17h15, will be the first time the Capetonians play at their new venue since moving away from DHL Newlands. All the action will be live on SuperSport.
Ferreira, who recently turned 38 years old, joined the Toyota Cheetahs on a two-year deal after he was out of contract for 10 months. The well-travelled front ranker previously turned out for Boland, DHL Western Province and the Stormers, Eastern Province, the Southern Kings and Toulouse in France.
The 29-year-old Bernardo returned to the Free State outfit from Japanese club Canon Eagles and has previously also played for Eastern Province, the Southern Kings and Welsh clubs Ospreys and Scarlets.
Pienaar's return will be good news for Toyota Cheetah supporters. The 2007 RWC winner is on the bench after being ruled out of action in the early rounds of Vodacom Super Rugby Unlocked last year, when he injured his knee against the Vodacom Bulls.
Hawies Fourie (coach) has picked a strong looking team despite injuries to several players - Charles Marais (neck), Junior Pokomela (wrist), William Small-Smith (concussion) and Louis van der Westhuizen (knee) are all unavailable.
Toyota Cheetahs: 15 Clayton Blommetjies, 14 Duncan Saal, 13 Chris Smit, 12 Frans Steyn, 11 Rosko Specman, 10 Reinhardt Fortuin, 9 Tian Meyer, 8 Jeandré Rudolph, 7 George Cronje, 6 Andisa Ntsila, 5 Rynier Bernardo, 4 Carl Wegner (captain), 3 Aranos Coetzee, 2 Wilmar Arnoldi, 1 Schalk Ferreira. Replacements: 16 Marnus van der Merwe, 17 Conraad van Vuuren, 18 Khutha Mchunu, 19 Victor Sekekete, 20 Aidon Davis, 21 Ruan Pienaar, 22 Dries Swanepoel, 23 Rhyno Smith.